Pharmacology PYQs – Set 126

By Atul Sahu • Pharmacology, Subject Wise PYQs

Pharmacology PYQs – Set 126

Subject : Pharmacology

2501. Which of the following is a third-generation cephalosporin?

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Cefazoline B. Cefuroxime C. Cefotaxime D. Cefepime

2502. Match the mechanisms: Methotrexate, Vinca alkaloids, Bleomycin, 5-Fluoro Uracil with their actions.

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Methotrexate – Inhibition of microtubules, Vinca alkaloids – Inhibition of purine synthesis, Bleomycin – Inhibition of RNA, 5-Fluoro Uracil – DNA damage B. Methotrexate – Inhibition of purine synthesis, Vinca alkaloids – Inhibition of microtubules, Bleomycin – DNA damage, 5-Fluoro Uracil – Inhibition of 2-deoxythymidylate synthesis C. Methotrexate – DNA damage, Vinca alkaloids – Inhibition of microtubules, Bleomycin – Inhibition of 2-deoxythymidylate, 5-Fluoro Uracil – RNA damage D. Methotrexate – DNA damage, Vinca alkaloids – RNA damage, Bleomycin – Inhibition of purine synthesis, 5-Fluoro Uracil – Inhibition of 2-deoxythymidylate synthesis

2503. Which combination of antiviral drugs is correctly paired?

Pharmacology • Antimicrobial Agents • GPAT 2023

A. NRTIs - Ritonavir B. Protease inhibitors - Indinavir C. Integrase inhibitors - Saquinavir D. NNRTIs - Tenofovir

2504. According to the SAR of Chloroquine electron:

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Donating group at 6th position of the quinoline ring is important for the inhibition of hemozoin formation B. Withdrawing group at 6th position of the quinoline ring is important for the inhibition of hemozoin formation C. Donating group at 7th position of the quinoline ring is important for the inhibition of hemozoin formation D. Withdrawing group at 7th position of the quinoline ring is important for the inhibition of hemozoin formation

2505. Which antibiotic undergoes light catalysed autoxidation:

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Sugar derived antibiotics B. Polyene antibiotics C. Macrolide antibiotics D. Beta lactum antibiotics

2506. Which is the active form of Ganciclovir?

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Triphosphate B. Biphosphate C. Tetraphosphate D. Phosphate

2507. Which of the following is first prodrug for sulfonamide:

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Sulfatrim B. Sulfamidochrysodine C. Trimethoprim D. Prontocil

2508. The fluoroquinolones act by:

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Inhibiting folic acid synthesis, reducing nucleotide production and DNA synthesis B. Inhibiting ribosomal subunits, leading to the cessation of protein synthesis C. Disrupting peptidoglycan cross-linking, weakening the bacterial cell wall D. Inhibiting DNA gyrase and topoisomerase IV, causing supercoiling and fragmentation of bacterial DNA

2509. What is the proposed mechanism of action of artemisinin in the treatment of malaria:

Pharmacology • Antimicrobial Agents • GPAT 2023

A. Blocking of the Plasmodium falciparum ATPase, disrupting ion homeostasis B. Inhibition of the heme polymerase enzyme, causing accumulation of toxic heme C. Inhibition of dihydrofolate reductase, interfering with folate synthesis D. Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death

2510. Meclofenamate belongs to which class of drugs?