Biopharmaceutics PYQs – Set 20

By Atul Sahu • Biopharmaceutics, Subject Wise PYQs

Biopharmaceutics PYQs – Set 20

Subject : Biopharmaceutics

381. Choose the correct statement for PEGylation:

Biopharmaceutics • ADME • GPAT 2015

A. Used to enhance in vivo half-life of small peptides and proteins B. Avoidance of reticuloendothelial clearance C. Reduction in renal clearance D. All of the above

382. If the given drug is absorbed by passive what will be its absorption kinetics?

Biopharmaceutics • ADME • GPAT 2015

A. Zero Order B. First Order C. Second order D. Pseudo-zero Order

383. Methenamine used for UTI is a prodrug. How and to what is it converted into?

Biopharmaceutics • ADME • GPAT 2015

A. At low pH of urine, to formaldehyde B. At high pH of urine, to aminosalicylic acid C. At low pH of urine, to aminosalicylic acid D. At high pH of urine, to formaldehyde

384. Identify the false statements regarding zero order kinetics and lipid diffusion absorption

Biopharmaceutics • ADME • GPAT 2015

A. Drugs eliminated by zero order kinetics have a half-life that is not constant B. The plasma concentration vs. time curve for zero order elimination is linear C. For first order processes, the rate is proportional to drug concentration D. Absorption by lipid diffusion is saturable at high drug concentrations

385. If a drug is highly bound to plasma proteins, what might be its consequence?

Biopharmaceutics • ADME • GPAT 2015

A. It is most likely carried by α‑glycoprotein B. It has a high renal clearance C. It has a large volume of distribution D. It is a likely candidate for drug interactions

386. Method of inspections used to determine the absorption rate constants assumes that

Biopharmaceutics • ADME • GPAT 2015

A. Ka is at least five times greater than the elimination rate B. Absorption is complete (>95%) at the time of peak concentration C. Both absorption and elimination are first order processes D. PandQ

387. If a drug is distributed into total body water, how many milligrams are needed to obtain an initial plasma level of 5 mg/L in a 70 kg patient?

Biopharmaceutics • ADME • GPAT 2015

A. 210 B. 150 C. 50 D. 35

388. What does “pharmacokinetic compartment” mean?

Biopharmaceutics • ADME • GPAT 2015

A. Part of the body water in the vascular system B. Total body water C. Plasma, intracellular fluid, and anatomical water compartments where the drug is absorbed D. Part of the body water in which the change in drug concentration has the same kinetics

389. Following intravenous administration, drugs are distributed fastest to

Biopharmaceutics • ADME • GPAT 2015

A. The skin, kidney, and brain B. The liver, kidney, and brain C. The liver, adipose tissue, and brain D. The liver, kidney, and adipose tissue

390. Which method is not suitable to calculate the area under the curve (AUC)?

Biopharmaceutics • ADME • GPAT 2015

A. Least square method B. Weighing and platometry C. Trapezoid rule D. Integration of curve

391. If the pKa of lidocaine is 7.9 and the pH of the infected tissue is 8.9, the fraction of drug in the ionized form will be

Biopharmaceutics • ADME • GPAT 2015

A. 0.1 B. 0.01 C. 0.9 D. 0.99

392. Apparent volume of distribution will be highest in case of the drug with which % plasma protein binding

Biopharmaceutics • ADME • GPAT 2015

A. 0.1 B. 0.89 C. 0.5 D. 0.68

393. Indicate which of the following statements is true

Biopharmaceutics • ADME • GPAT 2015

A. A weakly acidic drug is unionized when pH is ≥ 2 units below its pKa B. Acidic drugs are nonionized at pH 9 C. Acidic drugs are less soluble in alkaline solution D. The higher the pKa of a weak acid, the stronger the acid

394. The Michaelis‑Menten equation for a standard saturated active transport system is

Biopharmaceutics • ADME • GPAT 2015

A. V = kK [S] B. V = k [S] C. V = k[S] D. None

395. When Ke is constant and Ka is larger, the pharmacokinetic effect is:-

Biopharmaceutics • ADME • GPAT 2015

A. Cmax is higher and tmax is longer B. Cmax is lower and tmax is longer C. Cmax is lower and tmax is shorter D. Cmax is higher and tmax is shorter

396. When considering drug delivery to the brain, which of the following is false?

Biopharmaceutics • ADME • GPAT 2015

A. The blood vessel cells supplying the brain are tightly connected, restricting drug absorption B. Only relatively small lipophilic molecules passively diffuse into the brain C. Drugs with a low log P value show improved passive diffusion into the brain D. Polar molecules can be taken up into the brain through active transport

397. In pharmacokinetic models, the term “compartment” means:

Biopharmaceutics • ADME • GPAT 2015

A. Blood B. Individual organ C. Extracellular fluid D. Hypothetical pool of tissue

398. Which of the following drugs has an apparent volume of distribution of approximately 6500 liters?

Biopharmaceutics • ADME • GPAT 2015

A. Amoxicillin B. Ibuprofen C. Chloroquine D. Diazepam

399. A 70‑kg woman receives a 1000‑mg IV bolus of a drug, resulting in a plasma concentration of 50 mg/L. What is the volume of distribution?

Biopharmaceutics • ADME • GPAT 2015

A. 70 L B. 500 L C. 20 L D. 0.1 L

400. Which characteristic is most associated with a high apparent volume of distribution?

Biopharmaceutics • ADME • GPAT 2015

A. Penetration across blood–brain and blood–testis barriers B. Extensive plasma protein binding C. Distribution into total body water D. Extensive tissue binding

Disclaimer for MCQ Quiz
The questions in this MCQ quiz are intended solely for educational purposes. While we strive to ensure accuracy, the information may not always be up-to-date or complete. The creators are not liable for any errors or consequences. Verify any information before relying on it for critical decisions.

इस MCQ क्विज़ के प्रश्न केवल शैक्षिक उद्देश्यों के लिए हैं। हम सामग्री की सटीकता सुनिश्चित करने का प्रयास करते हैं, फिर भी जानकारी हमेशा अद्यतित या पूर्ण नहीं हो सकती। निर्माता किसी भी परिणाम के लिए जिम्मेदार नहीं हैं। कृपया किसी भी महत्वपूर्ण निर्णय से पहले स्वतंत्र रूप से जांचें।
https://www.growuppharma.in
यदि कोई गलती है या सुझाव हो तो ईमेल करें: growuppharmacy@gmail.com

Growup Pharma

Biopharmaceutics PYQs – Set 20

Biopharmaceutics PYQs – Set 20

Leave a Comment Cancel Reply

Biopharmaceutics PYQs – Set 20

Related Posts

Leave a Comment Cancel Reply