GPAT PYQs – Set 46

Year: 2014

904. According to Schedule 'Y' of the Drugs and Cosmetics Act, which statement regarding animal toxicity studies is incorrect?

Pharmaceutical Jurisprudence • Drugs and Cosmetics Act, 1940

A. Single dose human use – 2 weeks in 2 species B. Oral use for 2 weeks in humans – 4 weeks in 2 species C. Aerosol use by repeated dosing – 24 weeks in 2 species D. Multiple daily ocular application – irritation test in 1 species for 3 weeks

905. For determining the efficacy of sterilization in an autoclave, spores of which organism are used as test organisms?

Microbiology • Sterilization & Spore Testing

A. Bacillus cereus B. Clostridium perfringens C. Bacillus stearothermophilus D. Clostridium histolyticum

906. Which of the following pairs is mismatched?

Microbiology • Bacteriology

A. Aerobic, helical bacteria – gram negative B. Enterics – gram negative C. Mycobacteria – acid fast D. Pseudomonas – gram positive

907. List of drugs governed by special provisions is included in which schedule?

Pharmaceutical Jurisprudence • Drugs and Cosmetics Act, 1940

A. X B. K C. H D. G

908. Sigma minus method is used in the assessment of:

Pharmaceutical Jurisprudence • Quality Assurance & Auditing

A. Bioavailability B. Absorption C. Metabolism D. Tissue distribution

909. Which plant family contains volatile oil in their trichomes?

Pharmacognosy • Introduction to Pharmacognosy

A. Rutaceae B. Papaveraceae C. Umbelliferae D. Lamiaceae

910. Ferritin is:

Biochemistry • Protein Metabolism

A. Coenzyme B. The stored form of iron C. Non-protein moiety D. Isoenzyme

911. Which oil is soluble in alcohol?

Pharmaceutical Technology • Semisolid + Suppository + Aerosol

A. Arachis oil B. Sesame oil C. Castor oil D. Corn oil

912. One of the first steps of the citric acid cycle is the isomerization of citric acid to isocitric aciD : This step is necessary because:

Biochemistry • Citric Acid Cycle

A. Oxidation of a secondary alcohol is very difficult B. Reduction of a secondary alcohol is nearly impossible C. Reduction of tertiary alcohols would require a very powerful oxidizing agent D. Oxidation of a tertiary alcohol would require strong oxidizing agents

913. Which of the following alkyl halides would undergo an SN2 reaction most rapidly?

Organic Chemistry • General Organic Chemistry

A. CH₃CH₂Br B. CH₃CH₂Cl C. CH₃CH₂I D. CH₃CH₂F

914. Mechanism of action of Ketoconazole is primarily through:

Pharmacology • Antimicrobial Agents

A. Inhibition of ergosterol synthesis B. Inhibition of DNA gyrase C. Inhibition of dihydropteroate synthetase D. Induction of translation misreading

915. All are adrenal gland hyperactivity disorders EXCEPT:

Human Anatomy and Physiology • Endocrine Disorders

A. Addison's disease B. Conn’s syndrome C. Cushing’s syndrome D. Cushing's disease

916. The oil used in a parenteral product cannot contain:

Pharmaceutical Technology • Emulsion Formulation

A. WFI B. Paraffin oil C. Peanut oil D. Glycerine

917. Identify the non-absorbable suture among the following.

Pharmaceutical Technology • Sterile Dosage Forms

A. Catgut suture B. Chromic catgut suture C. Silk suture D. Polydioxanone suture

918. The relative lowering of vapor pressure is given by:

Physical and Inorganic Chemistry • Colligative Properties

A. Raoult’s law B. Henry’s law C. Boyle’s law D. Charles law

919. Methyl [5-(propylthio)-1H-benzoimidazol-2-yl] carbamate is the Geneva name of which drug?

Medicinal Chemistry • Antimicrobial Agents

A. Mebendazole B. Albendazole C. Thibendazole D. Triclabendazole

920. Match the following: (P) Gypsum salt, (Q) Epsom salt, (R) Alum, (S) Green vitriol with: (1) KAl(SO₄)₂·12H₂O, (2) FeSO₄·7H₂O, (3) CaSO₄·2H₂O, (4) MgSO₄·7H₂O.

Physical and Inorganic Chemistry • Inorganic Salts

A. P-1, Q-2, R-4, S-3 B. P-3, Q-4, R-1, S-2 C. P-4, Q-3, R-1, S-2 D. P-2, Q-4, R-1, S-3

921. Tinea capitis is a ringworm infection of which part of the body?

Microbiology • Medical Mycology

A. Feet B. Groin C. Head D. Nails

922. Rank the following compounds in order of increasing reactivity in electrophilic aromatic substitution: (P) Benzene, (Q) Toluene, (R) Nitrobenzene.

Organic Chemistry • General Organic Chemistry

A. Q < P < R B. R < P < Q C. Q < R < P D. P < Q < R

923. Dose dumping may be a general problem in the formulation of:

Pharmaceutical Technology • Controlled‑Release Technologies

A. Soft gelatin capsules B. Suppositories C. Modified release drug products D. None

Disclaimer for MCQ Quiz
The questions in this MCQ quiz are intended solely for educational purposes. While we strive to ensure accuracy, the information may not always be up-to-date or complete. The creators are not liable for any errors or consequences. Verify any information before relying on it for critical decisions.

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GPAT PYQs – Set 46

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