GPAT PYQs – Set 40

By Atul Sahu • GPAT PYQs

GPAT PYQs – Set 40

Year: 2015

784. In Parkinson’s disease, there is a predominant loss of dopaminergic neurons in the

Human Anatomy and Physiology • Neurological Disorders

A. Substantia nigra B. Cerebellum C. Cerebral cortex D. Locus ceruleus

785. At equilibrium, receptor occupancy is related to drug concentration by

Pharmacology • General Pharmacology

A. Henderson-Hasselbalch equation B. Hill–Langmuir equation C. Lineweaver–Burk equation D. Langmuir adsorption isotherm

786. Which method is not suitable to calculate the area under the curve (AUC)?

Biopharmaceutics • Bioavailability and Bioequivalence

A. Least square method B. Weighing and platometry C. Trapezoid rule D. Integration of the curve

787. OROS is a technology developed for/as

Pharmaceutical Technology • Controlled‑Release Technologies

A. Oral release rapid onset system B. Orally rapid disintegrating tablets C. Osmotic controlled oral drug delivery system D. Transdermal drug delivery system

788. Match the events in tablet manufacturing with the effects observed: 1. Rapid drying of coated tablets, 2. Use of a highly viscous solution, 3. Improper feed rate from hopper, 4. Excessive compression force

Pharmaceutical Technology • Tablet Coating & Compression

A. (a) 1-R, 2-S, 3-Q, 4-P B. (b) 1-R, 2-S, 3-P, 4-Q C. (c) 1-S, 2-R, 3-Q, 4-P D. (d) 1-R, 2-P, 3-5, 4-Q

789. What molecular feature is penicillin said to mimic?

Medicinal Chemistry • Name Reactions

A. Disaccharide of N‑acetylmuramic acid and N‑acetylglucosamine B. N‑acetylneuraminic acid C. The pentapeptide moiety of five glycine units D. The dipeptide moiety D‑Ala-D‑Ala

790. A clinical trial is being conducted with 1500 volunteers over 2 years. The trial is in which phase?

Pharmaceutical Jurisprudence • Drugs and Cosmetics Act, 1940

A. Phase 1 B. Phase 2 C. Phase 3 D. Phase 4

791. Which drug has not undergone a clinical trial for its use to decrease intracranial pressure?

Pharmacology • Drugs Acting on Autonomic Nervous System

A. Dideoxyinosine B. Zidovudine C. Acetazolamide D. Nicotine

792. Colloidal dispersions exhibit which type of rheology?

Physical Pharmacy • Rheology + Kinetics & Drug Stability

A. Newtonian B. Pseudoplastic C. Non-Newtonian D. Dilatant

793. Which of the reactive oxygen species is most dangerous to cells?

Biochemistry • Reactive Oxygen Species

A. Singlet oxygen B. Hydroxyl radical C. Superoxide D. Peroxide

794. The Gibbs Phase rule states that

Physical and Inorganic Chemistry • Physical and Inorganic Chemistry

A. It holds only for systems with more than one component B. It predicts a maximum of three phases in a one-component system C. It does not count phase compositions as intensive variables D. It does not count pressure and temperature as intensive variables

795. Nerve impulses from the cochlea arrive first in which region of the brain?

Human Anatomy and Physiology • Neuroanatomy

A. Auditory cortex B. Thalamus C. Medulla oblongata D. Inferior colliculus

796. The product of a Michael reaction between a ketone enolate and an α,β-unsaturated ketone is

Organic Chemistry • Name Reactions

A. 1,5-deketone; 1,4-fashion B. β-substituted acetate; 1,2-fashion C. β-hydroxy keto; 1,3-fashion D. α,β-keto ester; 1,5-fashion

797. Which of the following is a drug considered as potassium-sparing diuretic?

Pharmacology • Diuretics + Blood

A. Trimatrine B. Chlorthiazide C. Mannitol D. Furosemide

798. Which reagent from the given can be used to protect a ketone group?

Organic Chemistry • Name Reactions

A. Acidic methanol B. Basic methanol C. Methanol + KCN D. None of these

799. Which of the following drugs causes less inhibition of REM sleep?

Pharmacology • Drugs Acting on Central Nervous System

A. Zolpidem B. Ethanol C. Lorazepam D. Phenobarbitone

800. What structure is formed if the acyl side chain of penicillin is hydrolyzed?

Medicinal Chemistry • Name Reactions

A. Penicillienic acids B. Penillic acids C. 7-Aminopenicillanic acid D. 6-Aminopenicillanic acid

801. Match the following plant products with their chemical classes: 1. β-Amyrin, 2. Squalene, 3. Morphine, 4. Ephedrine

Pharmacognosy • Introduction to Pharmacognosy

A. (a) 1-R, 2-S, 3-Q, 4-P B. (b) 1-5, 2-Q, 3-P, 4-R C. (c) 1-P, 2-S, 3-Q, 4-R D. (d) 1-R, 2-S, 3-P, 4-Q

802. All of the following except one are subject to therapeutic drug monitoring. Which one?

Pharmacology • General Pharmacology

A. Phenytoin B. Lithium C. Gentamicin D. Losartan

803. Thiamine deficiency causes decreased energy production because

Biochemistry • Enzymes and Coenzymes

A. It is required for transamination B. It is a co-factor in oxidative reduction C. It is a coenzyme for transketolase in the pentose phosphate pathway D. It is a coenzyme for pyruvate dehydrogenase & α-ketoglutarate dehydrogenase

Disclaimer for MCQ Quiz
The questions in this MCQ quiz are intended solely for educational purposes. While we strive to ensure accuracy, the information may not always be up-to-date or complete. The creators are not liable for any errors or consequences. Verify any information before relying on it for critical decisions.

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GPAT PYQs – Set 40

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