GPAT PYQs – Set 32

Year: 2016

621. Which of the following is a Phase I drug metabolism reaction associated with genetic polymorphism?

Pharmacology • General Pharmacology

A. Glucuronidation B. Acetylation C. Reduction D. Glutathione conjugation

622. A gram-negative diplococcus associated with urinary tract infection, pelvic inflammatory disease, conjunctivitis, and meningitis is

Microbiology • Complete Subject

A. Neisseria gonorrhoeae B. Chlamydia trachomatis C. Haemophilus influenzae D. Streptococcus pneumoniae

623. Pregnancy test kits are designed to detect

Pharmacology • Drugs Acting on Endocrine System

A. Estrogen B. Human chorionic gonadotropin C. Follicle-stimulating hormone D. Luteinizing hormone

624. Drug Z is a depolarizing neuromuscular blocking agent effective for the treatment of pinworm. Identify drug Z.

Pharmacology • Drugs Acting on Autonomic Nervous System

A. Phyrantel B. Paramomycin C. Integrase D. Protease

625. Methenamine used for UTI is a prodrug. How and to what is it converted into?

Biopharmaceutics • ADME

A. At low pH of urine, to formaldehyde B. At high pH of urine, to aminosalicylic acid C. At low pH of urine, to aminosalicylic acid D. At high pH of urine, to formaldehyde

627. Match the following enzymes/proteins with specific functions in DNA replication: 1. Helicases, 2. DNA Primase, 3. DNA Ligases, 4. Topoisomerases

Biochemistry • Enzymes and Coenzymes

A. (a) 1-P, 2-Q, 3-R, 4-S B. (b) 1-P, 2-S, 3-Q, 4-R C. (c) 1-S, 2-Q, 3-P, 4-R D. (d) 1-P, 2-Q, 3-R, 4-S

628. Which is the first-line drug for the treatment of generalized seizures?

Pharmacology • Drugs Acting on Central Nervous System

A. Valproic acid B. Anhydrotetracycline C. Carbamazepine D. Doxycycline

629. Which one among the following drugs has the IUPAC name α,α,α,α‑tetramethyl 5‑(1H‑1,2,4‑triazole‑1‑ylmethyl)‑1,3‑benzenediacetonitrile:

Medicinal Chemistry • Heterocyclic Chemistry

A. Letrozole B. Anastrozole C. Exemestane D. Aminoglutethimide

630. The location of the blood-brain barrier is considered to be

Human Anatomy and Physiology • Complete Subject

A. At the level of the brain capillaries B. At the level of glia C. At the level of neurons D. At the level of dendrites

631. The following drug metabolizing reaction occurs entirely non-microsomally:

Pharmacology • General Pharmacology

A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction

632. Which of the following methods is used to determine whether a process functions properly for its intended use?

Pharmaceutical Jurisprudence • Drugs and Cosmetics Act, 1940

A. Capacity B. Inspection C. Validation D. Design Review

633. Match product, source, and plant part from which they are obtained: 1. Bacosides, 2. Cutch, 3. Henna, 4. Alizarm

Pharmacognosy • Introduction to Pharmacognosy

A. (a) 1-R-ii, 2-S-I, 3-Q-iii, 4-P-iv B. (b) 1-R-I, 2-P-iv, 3-S-ii, 4-Q-i C. (c) 1-Q-ii, 2-P-iii, 3-S-iv, 4-R-I D. (d) 1-S-ii, 2-R-iv, 3-P-I, 4-Q-i

634. What is the significance of the term “overfill”?

Pharmaceutical Technology • Preformulation

A. It is similar to overage B. It is the excess volume filled in containers (e.g., vials, ampoules) to avoid loss by degradation C. It is the excess filling of containers to avoid loss during packaging D. It is a violation of packaging regulation as per GMP

635. Identify the false statements regarding zero order kinetics and lipid diffusion absorption

Biopharmaceutics • ADME

A. Drugs eliminated by zero order kinetics have a half-life that is not constant B. The plasma concentration vs. time curve for zero order elimination is linear C. For first order processes, the rate is proportional to drug concentration D. Absorption by lipid diffusion is saturable at high drug concentrations

636. Select the correct set of anticancer drugs that belong to pyrimidine and related compounds:

Medicinal Chemistry • Heterocyclic Chemistry

A. 5‑Flurouracil, Tegafur, Decitabine, 5‑Azacytidine B. 5‑Flurouracil, Tegafur, Decitabine, Clofarabine C. Tegafur, Decitabine, 5‑Azacytidine, Clofarabine D. Tegafur, Decitabine, 5‑Azacytidine, Pentostatin

637. Oseltamivir is an antiviral drug. It produces its action by inhibiting which enzyme?

Pharmacology • Antimicrobial Agents

A. DNA polymerase B. Neuraminidase C. Praziquantel D. Ivermectin

638. The following are the processes occurring during flame atomization in atomic absorption spectrometry A. Volatilization B. Ionization C. Nebulization D : Desolvation E. Dissociation Arrange the processes in sequential order and choose the correct answer

Pharmaceutical Analysis • Spectroscopy

A. C, B, A, D, E B. C, D, E, B, A C. A, C, D, B, E D. C, D, A, E, B

639. Which problem can arise if the material to be compressed into a tablet tends to adhere to die walls?

Pharmaceutical Technology • Tablet

A. Picking B. Sticking C. Capping D. Marbling

640. What is the half-life of Tc-99m?

Pharmaceutical Technology • Preformulation

A. 66 years B. 66 hours C. 6 hours D. 60 minutes

641. Eudragits are

Pharmaceutical Technology • Tablet

A. Phthalate polymers B. Cellulose polymers C. Acrylate polymers D. Amide polymers

Disclaimer for MCQ Quiz
The questions in this MCQ quiz are intended solely for educational purposes. While we strive to ensure accuracy, the information may not always be up-to-date or complete. The creators are not liable for any errors or consequences. Verify any information before relying on it for critical decisions.

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GPAT PYQs – Set 32

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