NIPER PYQs – Set 91

By Atul Sahu • NIPER PYQs

NIPER PYQs – Set 91

Year: 2020

1801. Pramipexole is

Pharmacology & Toxicology • Dopamine Agonists

A. Antipsychotic B. Antidepressant C. Anthelmentic D. Antiparkinsonial

1802. Single letter symbol for arginine is

Pharmaceutical Biotechnology • Amino Acid Codes

A. K B. D C. R D. G

1803. Penicillin degradation is prevented at pH

Pharmaceutics & Formulation • Stability

A. 4 B. 5 C. 6 D. 8

1804. Which of the following titration method should be protected from light?

Pharmaceutical Analysis • Titrimetric Methods

A. Volhard B. Adsorption C. Mohr D. Gay Lussac

1805. If the rate constant for a first order reaction is k, the time(t) required for the completion of 99% of the reaction is given by

Pharmaceutical Analysis • Kinetics

A. t = 4.606/k B. t = 2.303/k C. t = 0.693/k D. t = 6.909/k

1806. Assessment, control, communication and review of risks to the quality of the drug product across the product life cycle is

Regulatory Affairs & IPR • Quality Risk Management

A. QbD B. QRM C. PAT D. QTPP

1807. Which one of the following is a Histamine H1-receptor antagonist?

Pharmacology & Toxicology • Antihistamines

A. 4-(5H-dibenzola,d] cyclohepten-5-ylidene)-1-methyl pyridine hydrochloride B. 4-(5H-dibenzola,d] cyclohepten-5-ylidene)-1-methyl pyrimidine hydrochloride C. 4-(5H-dibenzo[a,d] cyclohepten-5-ylidene)-1-methyl piperidine hydrochloride D. 4-(5H-dibenzoja,d] cycloheptane-5-ylidene)-1-methyl piperidine hydrochloride

1808. QbD is described in ICH guidelines

Regulatory Affairs & IPR • Quality by Design

A. Q8 Part I B. Q8 Part II C. Q9 D. Q10

1809. Which is the correct long term stability condition for zone IVb?

Pharmaceutics & Formulation • Stability Testing

A. 40 °C ± 2 °C/75% ± 5% B. 30 °C ± 2 °C/65% ± 5% C. 30 °C ± 2 °C/75% ± 5% D. None

1810. Which medicine works by binding to the glycoprotein llb/llla receptor, reversibly inhibiting platelet aggregation?

Pharmacology & Toxicology • Antiplatelet Agents

A. Clopidogrel B. Warfarin C. Ticlopidine D. Eptifibatide

1811. Which is the most stable structure of 1-isopropyl-4-methylcyclohexane?

Organic Chemistry & Bulk Drugs • Conformational Analysis

A. Both groups axial B. Both groups equitorial C. Bigger group axial smaller equitorial D. Bigger group equitorial smaller group axial

1812. Only percent of the effluent of the liquid chromatography must be introduced in the mass spectrometer

Pharmaceutical Analysis • Instrumental Analysis

A. 1-20% B. 1-15% C. 1-5% D. Below 1%

1813. In AAS, ionization of analyte atoms in flame/plasma can be suppressed by

Pharmaceutical Analysis • Atomic Absorption

A. EDTA or other complexing agents B. Addition of KCl to the matrix C. Addition of oxyanions such as sulfate or phosphate D. Internal standards methods

1814. Furan is aromatic. What is the value of Hukel's n in it?

Organic Chemistry & Bulk Drugs • Aromaticity

A. 1 B. 2 C. 4 D. 6

1815. Which feature in the 1H NMR spectrum provides information about the electronic environment of the protons in a compound?

Pharmaceutical Analysis • NMR Spectroscopy

A. splitting B. chemical shift C. integral D. number of signals

1816. What is the relationship between the following two structures?

Organic Chemistry & Bulk Drugs • Stereochemistry

A. tautomers B. stereoisomers C. resonance structures D. constitutional isomers, but not tautomers

1817. Systemic clearance (CLs) is related with

Pharmacology & Toxicology • Pharmacokinetics

A. Only the concentration of substances in plasma B. Only the elimination rate constant C. Volume of distribution, half life and elimination rate constant D. Bioavailability and half life

1818. Reversible uncompetitive enzyme inhibition occurs when the inhibitor binds to

Pharmaceutical Biotechnology • Enzyme Inhibition

A. enzyme-substrate complex (ES) only B. free enzyme at substrate binding site C. enzyme at a site different from substrate binding site D. enzyme-substrate complex but at a site different from substrate binding site

1819. The observations of study of hydrolysis of a drug in an aqueous solution were plotted as a logarithm of the amount of drug remaining (on Y-axis) against time (on X-axis) and was found to be linear. What might be the correct inference?

Pharmaceutical Analysis • Reaction Kinetics

A. The reaction is zero-order B. The slope is 2.303/k C. The units of k are concentration^-1 time^-1 D. The half-life is t1/2 = 0.693/k

1820. Attention deficit hyperactivity disorder (ADHD) may be treated with behavior management, educational programs, parental counseling and medications. Which of the following medications is NOT generally used in the treatment of ADHD in children?

Pharmacology & Toxicology • CNS Drugs

A. methylphenidate B. dexamphetamine C. imipramine D. clonazepam

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NIPER PYQs – Set 91

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