NIPER PYQs – Set 5

Year: 2010

81. An effective antidote in cyanide poisoning is:

Pharmacology & Toxicology • Antidotes

A. Pralidoxime B. Erythrityl trinitrate C. Atropine D. Flumazenil

82. Allosteric binding means –––––.

Pharmacology & Toxicology • Receptor Binding

A. Binding of the substrate at the active site of the enzyme B. Binding to a site other than the active binding site on the same enzyme C. Binding to the enzyme-substrate complex D. Binding to the endogenous substrate

83. Most intense peak obtained in mass spectrum is –––––––.

Pharmaceutical Analysis • Mass Spectrometry

A. Molecular ion peak B. Base peak C. Parent ion peak D. Isotopic peak

84. IND application filling is done before ––––––.

Regulatory Affairs & IPR • IND Filing

A. Preclinical study B. Clinical trials C. Patent registration D. Marketing

85. Which of the following is false regarding Oppenauer oxidation?

Organic Chemistry & Bulk Drugs • Oxidation Reactions

A. The alcohol is oxidized with aluminum isopropoxide in excess acetone. B. DMP is used as the reaction catalyst C. Highly selective for secondary alcohols D. Pregnenolone converted to progesterone

86. Which of the following is true about diastereoisomers?

Medicinal Chemistry • Stereochemistry

A. Stereoisomers having multiple chiral centers, cannot be superimposed on the mirror image of another. B. Configuration isomerism and conformational isomerism are also forms of diastereomerism C. Diastereomers have different physical properties and different reactivity. D. All of the above

87. Electrophilic aromatic substitution reaction using a strong Lewis acid catalyst is known as –––– –.

Organic Chemistry & Bulk Drugs • Friedel-Crafts Reaction

A. Clemmensen reduction B. Wolff-Kishner reduction C. Friedel-Crafts reaction D. None of the above

88. Splitting of a spectral line into several components due to a magnetic field is known as –––––––.

Pharmaceutical Analysis • Spectroscopy (Zeeman Splitting)

A. Hamiltonian effect B. Zeeman effect C. Stark effect D. Magnetic effect

89. Arrange the following in correct bond energy sequence:

Organic Chemistry & Bulk Drugs • Bond Energy

A. C-Cl < C-C < C-H < H-H B. H-H < C-H < C-C < C-Cl C. C-Cl < C-H < C-C < H-H D. C-Cl < C-H < H-H < C-C

90. Salk vaccine is ––––––––.

Pharmaceutical Biotechnology • Vaccines

A. Injected dose of dead poliovirus B. Oral dose of live attenuated poliovirus C. Injected dose of live attenuated poliovirus D. Oral dose of dead poliovirus

91. Why is PEG used in liposome?

Pharmaceutics & Formulation • Liposome Formulation

A. To enhance drug loading capacity B. To form an effective bi-layer C. To modify the release of drug D. Avoid detection by the body's immune system

92. DCC is used in ––––––––.

Organic Chemistry & Bulk Drugs • Coupling Reactions

A. Bechamp reduction B. Benkeser reduction C. Birch reduction D. Solid-phase peptide synthesis

93. Diazepam is ––––––––.

Pharmacology & Toxicology • Benzodiazepines

A. Antipsychotic B. Antidepressant C. Minor tranquilizer D. Hallucinogen

94. Which of the following is a stop code for translation?

Pharmaceutical Biotechnology • Genetic Code

A. UAA B. UGA C. UAG D. All of the above

95. Which of the following antioxidants is a reducing agent?

Pharmacology & Toxicology • Antioxidants

A. α-Tocopherol B. BHT C. Vitamin C D. All of the above

96. Autoimmune disorder myasthenia gravis is caused by ––––––––.

Pharmacology & Toxicology • Immunological Disorders

A. Destruction of articular cartilage and ankylosis of the joints B. Circulating antibodies that block ACh receptors at the postsynaptic neuromuscular junction C. Antigen-antibody reaction which destructs the neuromuscular junction D. Deficiency of ACh at the neuronal junction

97. Which of the following is a prodrug?

Medicinal Chemistry • Prodrugs

A. Sulfasalazine B. Sulindac C. Aspirin D. Siloxane

98. Which of the following reacts via benzyne intermediate?

Organic Chemistry & Bulk Drugs • Reaction Mechanisms

A. C₆H₅NO₂ B. C₆H₃NO₂Cl₂, ortho-Cl, ortho-Cl C. C₆H₂NO₂Cl3 ortho-Cl, ortho-Cl, para-Cl. D. C₆H₄NO₂Cl, para-Cl.

99. Which scientist coined the term antibiotic?

General Knowledge • Historical Scientific Terms

A. Fleming B. Domagk C. Ehrlich D. Waksman

100. Which is used as sweetening agent in chewable tablets?

Pharmaceutics & Formulation • Excipients

A. Anhydrous lactose B. Mannitol C. Sodium saccharin D. Menthol

Disclaimer for MCQ Quiz
The questions in this MCQ quiz are intended solely for educational purposes. While we strive to ensure accuracy, the information may not always be up-to-date or complete. The creators are not liable for any errors or consequences. Verify any information before relying on it for critical decisions.

इस MCQ क्विज़ के प्रश्न केवल शैक्षिक उद्देश्यों के लिए हैं। हम सामग्री की सटीकता सुनिश्चित करने का प्रयास करते हैं, फिर भी जानकारी हमेशा अद्यतित या पूर्ण नहीं हो सकती। निर्माता किसी भी परिणाम के लिए जिम्मेदार नहीं हैं। कृपया किसी भी महत्वपूर्ण निर्णय से पहले स्वतंत्र रूप से जांचें।
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NIPER PYQs – Set 5

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